Image courtesy of Adrian Streit
Strongyloides spp. are gastrointestinal parasites of humans and other animals, estimated to infect ~150 million people globally as well as causing substantial loss to livestock practices. Two species, S. ratti and S. venezuelensis are natural parasites of rodents and offer ideal laboratory models to study nematode parasitism.
We want to understand how parasitic nematodes infect their host at a molecular and genetic level. Our research investigates the protein-coding genes and the small RNAs that have a role in nematode parasitism. We use the parasitic nematode Strongyloides ratti, a gastrointestinal of rodents, as a model to understand nematode parasitism.
We have also started working with freeliving Caenorhabditis nematodes including C. inopinata, a recently discovered sibling species of C. elegans, to better understand the diversity of small RNA pathways in nematodes.